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Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

Current Alzheimer research - 1 Jan 2017

Zorzetto Michele, Datturi Francesca, Divizia Laura, Pistono Cristiana, Campo Ilaria, De Silvestri Annalisa, Cuccia Mariaclara, Ricevuti Giovanni

Abstract excerpt

BACKGROUND/OBJECTIVES: Increasing evidence suggests the importance of neuroinflammation in the pathogenesis of Alzheimer's disease (AD), which is a complex neurodegenerative disorder. Complement activation occurs in the brain of patients with AD and seems to contribute to an important local inflammatory state. Increased expression of the fourth serum complement component 4 (C4) has been observed in AD patients in...

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Identifiers

PMID: 27758680
DOI: 10.2174/1567205013666161013091934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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