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Article

Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD).

Journal of neuroinflammation - 18 Apr 2016

Grassmann Felix, Cantsilieris Stuart, Schulz-Kuhnt Anja-Sabrina, White Stefan J, Richardson Andrea J, Hewitt Alex W, Vote Brendan J, Schmied Denise, Guymer Robyn H, Weber Bernhard H F, Baird Paul N

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of vision loss in Western societies with a strong genetic component. Candidate gene studies as well as genome-wide association studies strongly implicated genetic variations in complement genes to be involved in disease risk. So far, no association of AMD with complement component 4 (C4) was reported probably due to the complex nature of the...

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Identifiers

PMID: 27090374
DOI: 10.1186/s12974-016-0548-0
PMCID: PMC4835888

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CFB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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