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Article

Investigation of complement component C4 copy number variation in human longevity.

PloS one - 1 Jan 2014

Flachsbart Friederike, Caliebe Amke, Heinsen Femke-Anouska, Hemming-Karlsen Tom, Schreiber Stefan, Franke Andre, Nebel Almut

Abstract excerpt

Genetic factors have been estimated to account for about 25% of the variation in an adult's life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences in the overall C4 copy number or gene size (long C4L; short C4S) may influence the strength of the immune response and disease susceptibilities. Previously, an association between C4B copy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24465950
DOI: 10.1371/journal.pone.0086188
PMCID: PMC3899116

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