Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue.

Oncotarget - 13 Dec 2016

Rouaud Florian, Boucher Jean-Luc, Slama-Schwok Anny, Rocchi Stéphane

Abstract excerpt

Melanoma is one of the most lethal cancers when it reaches a metastatic stage. Despite the spectacular achievements of targeted therapies (BRAF inhibitors) or immuno-therapies (anti-CTLA4 or anti-PD1), most patients with melanoma will need additional treatments. Here we used a photoactive NADPH analogue called NS1 to induce cell death by inhibition of NADPH oxidases NOX in melanoma cells, including melanoma cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Endoplasmic Reticulum Stress
Share to Microtubule-Associated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Oxidases

Share to RAW 264.7 Cells

Share to Reactive Oxygen Species

Share to Sequestosome-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 27756874
DOI: 10.18632/oncotarget.12651
PMCID: PMC5347734

Genes

BRAF
CTLA4
NOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue.PMID 27756874Read ↗

Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapySemantic proximity Read ↗

Role of ROS‑mediated autophagy in melanoma (Review)Semantic proximity Read ↗

Cell death: The underlying mechanisms of photodynamic therapy for skin diseasesSemantic proximity Read ↗

A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinson’s disease: key roles for TRPM2, Zn <sup>2+</sup> and complex IIISemantic proximity Read ↗

Taming ROS: Mitochondria-Targeted AIEgen for Neuron Protection via Photosensitization-Triggered AutophagySemantic proximity Read ↗

Increasing Autophagy ameliorate all-trans-retinal-activated NLRP3 Inflammasome 2 in human THP-1 macrophage cellsSemantic proximity Read ↗

Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cellsSemantic proximity Read ↗

Dysfunction of various organelles provokes multiple cell death after quantum dot exposureSemantic proximity Read ↗

Lipofuscin in keratinocytes: Production, properties, and consequences of the photosensitization with visible lightSemantic proximity Read ↗

Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expressionSemantic proximity Read ↗

Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.Semantic proximity Read ↗

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.