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Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression

12 Jun 2017

Abstract excerpt

Pharmacological levels of ascorbate have long been suggested as a potential treatment of cancer. However, we observed that EC50 of ascorbate was at a similar level for cultured healthy melanocytes and melanoma cells, suggesting a limit of pharmacological ascorbate in treating cancer. Loss of 5-hydroxymethylcytosine (5 hmC) is an epigenetic hallmark of cancer and ascorbate promotes 5 hmC generation by serving as a...

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PMID: 28623268
DOI: 10.1038/s41598-017-03893-5

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