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Article

Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells

14 May 2021

Abstract excerpt

Abstract The innate response of melanocytes to exogenous or endogenous stress stimuli like extreme pH and temperature, metabolite and oxygen deficiency or a high UV dose initiates a cellular stress response. This process activates adaptive processes to minimize the negative impact of the stressor on the pigment cell. Under physiological conditions, a non-cancer cell is directed to apoptosis if the stressor...

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PMID: 33990669
DOI: 10.1038/s41598-021-89792-2

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