Article

Taming ROS: Mitochondria-Targeted AIEgen for Neuron Protection via Photosensitization-Triggered Autophagy

2020-12-02

Abstract excerpt

Oxidative damages lead to accumulated harmful wastes, which in turn aggravate the related diseases and ROS imbalance. Therefore, provoking the defense system against severe oxidation and maintaining ROS homeostasis are desired. Herein, we used a mitochondria-targeted aggregation-induced emission luminogen (AIEgen) as a phototherapy agent for neuron protection by virtue of its efficient ROS generation in aggregates...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 528e4281-e409-5b75-a515-aec491a7e63c
DOI: 10.26434/chemrxiv.13134695.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Taming ROS: Mitochondria-Targeted AIEgen for Neuron Protection via Photosensitization-Triggered AutophagyDOI 10.26434/chemrxiv.13134695.v1Read

Hydrogen Peroxide-Responsive AIE Probe for Imaging-Guided Organelle Targeting and Photodynamic Cancer Cell AblationSemantic proximity Read

The Interrelation between Reactive Oxygen Species and Autophagy in Neurological DisordersSemantic proximity Read

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicineSemantic proximity Read

Multifunctional AIE Iridium (III) Photosensitizer Nanoparticles for Two-Photon-Activated Imaging and Mitochondria Targeting Photodynamic TherapySemantic proximity Read

Photodynamic Controls of Harmful Algal Blooms by an Ultra-efficient and Degradable AIEgen-based PhotosensitizerSemantic proximity Read

Fullerenols hijack lysosomes to disrupt inter-organellar crosstalk and block autophagy pre-activated by mTOR inhibitors for cancer cell PANoptosisSemantic proximity Read

Bioorganic Two-Photon Nanoprobes with a Photo-Oxidation Enhanced Emission MechanismSemantic proximity Read

Potentiating light-harvest tactics through A-D-A structure: repolarization tumor associated macrophage through phototherapySemantic proximity Read

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/COSemantic proximity Read

Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric <i>p</i> -Phenylene EthynylenesSemantic proximity Read

Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.Semantic proximity Read

Copper-containing ROS-scavenging nanozyme paradoxically drives α-synucleinopathy by amplifying nitrosative stressSemantic proximity Read