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Lipofuscin in keratinocytes: Production, properties, and consequences of the photosensitization with visible light

15 Aug 2020

Abstract excerpt

A dysfunction in the mitochondrial-lysosomal axis of cellular homeostasis is proposed to cause cells to age quicker and to accumulate lipofuscin. Typical protocols to mediate lipofuscinogenesis are based on the induction of the senescent phenotype either by allowing many consecutive cycles of cell division or by treating cells with physical/chemical agents such as ultraviolet (UV) light or hydrogen peroxide. Due...

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PMID: 32810634
DOI: 10.1016/j.freeradbiomed.2020.08.002

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