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Article

Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study.

Biochimica et biophysica acta. Biomembranes - 1 Jan 2017

Unsay Joseph D, Cosentino Katia, Sporbeck Katharina, García-Sáez Ana J

Abstract excerpt

Bcl-2 proteins are key regulators of the mitochondrial outer membrane (MOM) permeabilization that mediates apoptosis. During apoptosis, Bid is cleaved (cBid) and translocates to the MOM, where it activates Bax. Bax then oligomerizes and induces MOM permeabilization. However, little is known about how these proteins affect membrane organization aside from pore formation. In previous studies, we have shown that...

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PMID: 27755971
DOI: 10.1016/j.bbamem.2016.10.007

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AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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