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Article

Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.

The Journal of biological chemistry - 25 Dec 2020

Morris Daniel L, Johnson Sabrina, Bleck Christopher K E, Lee Duck-Yeon, Tjandra Nico

Abstract excerpt

Members of the B-cell lymphoma (BCL-2) protein family regulate mitochondrial outer membrane permeabilization (MOMP), a phenomenon in which mitochondria become porous and release death-propagating complexes during the early stages of apoptosis. Pro-apoptotic BCL-2 proteins oligomerize at the mitochondrial outer membrane during MOMP, inducing pore formation. Of current interest are endogenous factors that can...

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PMID: 33106313
DOI: 10.1074/jbc.RA120.013023

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Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers.PMID 33106313Read ↗

Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.Semantic proximity Read ↗

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Humanin variants aggregate to produce different fibril morphologies.Semantic proximity Read ↗

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Semantic proximity Read ↗

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Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Semantic proximity Read ↗

An optimized high-yield protocol for expression and purification of monomeric full-length BAX proteinSemantic proximity Read ↗

Bax Forms a Membrane Surface Protein-Lipid Complex as it Initiates ApoptosisSemantic proximity Read ↗

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.Semantic proximity Read ↗

BID-induced structural changes in BAK promote apoptosis.Semantic proximity Read ↗

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core.Semantic proximity Read ↗

tBid undergoes multiple conformational changes at the membrane required for Bax activation.Semantic proximity Read ↗

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