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Article

tBid undergoes multiple conformational changes at the membrane required for Bax activation.

The Journal of biological chemistry - 26 Jul 2013

Shamas-Din Aisha, Bindner Scott, Zhu Weijia, Zaltsman Yehudit, Campbell Clinton, Gross Atan, Leber Brian, Andrews David W, Fradin Cécile

Abstract excerpt

Bid is a Bcl-2 family protein that promotes apoptosis by activating Bax and eliciting mitochondrial outer membrane permeabilization (MOMP). Full-length Bid is cleaved in response to apoptotic stimuli into two fragments, p7 and tBid (p15), that are held together by strong hydrophobic interactions until the complex binds to membranes. The detailed mechanism(s) of fragment separation including tBid binding to...

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Identifiers

PMID: 23744079
DOI: 10.1074/jbc.M113.482109
PMCID: PMC3724664

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