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Article

tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation.

The Journal of biological chemistry - 24 Nov 2006

Peng Jun, Tan Chibing, Roberts G Jane, Nikolaeva Olga, Zhang Zhi, Lapolla Suzanne M, Primorac Steve, Andrews David W, Lin Jialing

Abstract excerpt

During initiation of apoptosis, Bcl-2 family proteins regulate the permeability of mitochondrial outer membrane. BH3-only protein, tBid, activates pro-apoptotic Bax to release cytochrome c from mitochondria. tBid also activates anti-apoptotic Bcl-2 in the mitochondrial outer membrane, changing it from a single-spanning to a multispanning conformation that binds the active Bax and inhibits cytochrome c release....

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Identifiers

PMID: 17005564
DOI: 10.1074/jbc.M608303200
PMCID: PMC2825177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation.PMID 17005564Read ↗

tBid undergoes multiple conformational changes at the membrane required for Bax activation.Semantic proximity Read ↗

Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.Semantic proximity Read ↗

Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.Semantic proximity Read ↗

The deadly landscape of pro‐apoptotic BCL ‐2 proteins in the outer mitochondrial membraneSemantic proximity Read ↗

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.Semantic proximity Read ↗

The destabilization of lipid membranes induced by the C-terminal fragment of caspase 8-cleaved bid is inhibited by the N-terminal fragment.Semantic proximity Read ↗

Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif.Semantic proximity Read ↗

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Semantic proximity Read ↗

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.Semantic proximity Read ↗

Cleavage of Bid by Executioner Caspases Mediates Feed Forward Amplification of Mitochondrial Outer Membrane Permeabilization during Genotoxic Stress-induced Apoptosis in Jurkat CellsSemantic proximity Read ↗

Bid Protein: A Participant in the Apoptotic Network with Roles in Viral InfectionsSemantic proximity Read ↗

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Semantic proximity Read ↗

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