Article
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.
Developmental cell - 1 Jan 2002
Scorrano Luca, Ashiya Mona, Buttle Karolyn, Weiler Solly, Oakes Scott A, Mannella Carmen A, Korsmeyer Stanley J
Abstract excerpt
The mechanism during apoptosis by which cytochrome c is rapidly and completely released in the absence of mitochondrial swelling is uncertain. Here, we show that two distinct pathways are involved. One mediates release of cytochrome c across the outer mitochondrial membrane, and another, characterized in this study, is responsible for the redistribution of cytochrome c stored in intramitochondrial cristae. We...
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