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Article

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases

14 Aug 2019

Abstract excerpt

Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function. Dysregulation of HNF4α...

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PMID: 31435165
DOI: 10.3748/wjg.v25.i30.4074

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