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Article

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.

Expert opinion on drug metabolism & toxicology - 1 Feb 2009

Chiang John Y L

Abstract excerpt

The hepatocyte nuclear factor 4alpha (HNF4alpha) is a liver-enriched nuclear receptor that plays a critical role in early morphogenesis, fetal liver development, liver differentiation and metabolism. Human HNF4alpha gene mutations cause maturity on-set diabetes of the young type 1, an autosomal dominant non-insulin-dependent diabetes mellitus. HNF4alpha is an orphan nuclear receptor because of which the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19239393
DOI: 10.1517/17425250802707342
PMCID: PMC3645476

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