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Heterozygosity for neurodevelopmental disorder-associated <i>TRIO</i> variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

2024-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Genetic variants in TRIO are associated with neurodevelopmental disorders (NDDs) including schizophrenia (SCZ), autism spectrum disorder (ASD) and intellectual disability. TRIO uses its two guanine nucleotide exchange factor (GEF) domains to activate GTPases (GEF1: Rac1 and RhoG; GEF2: RhoA) that control neuronal development and connectivity. It remains unclear how discrete TRIO variants diffe...

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Literature Corpus work
5ae9ec62-16d1-5d1f-bdca-5e362335ef25
DOI
10.1101/2024.01.05.574442
Open publication

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Heterozygosity for neurodevelopmental disorder-associated <i>TRIO</i> variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in miceDOI 10.1101/2024.01.05.574442
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