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Article

Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis

5 Dec 2006

Abstract excerpt

BACKGROUND: It has been proved that cyclo-oxygenase-2 (COX-2) is rapidly induced by inflammatory mediators. However, it is not known whether overexpression of COX-2 in the liver is sufficient to promote activation or secretion of inflammatory factors leading to hepatitis. AIM: To investigate the role forced expression of COX-2 in liver by using inducible COX-2 transgenic (TG) mice. METHODS: TG mice that...

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Identifiers

PMID: 17148503
DOI: 10.1136/gut.2006.097923

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