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Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma.

Cancer research - 1 Oct 2016

Lamy Philippe, Nordentoft Iver, Birkenkamp-Demtröder Karin, Thomsen Mathilde Borg Houlberg, Villesen Palle, Vang Søren, Hedegaard Jakob, Borre Michael, Jensen Jørgen Bjerggaard, Høyer Søren, Pedersen Jakob Skou, Ørntoft Torben F, Dyrskjøt Lars

Abstract excerpt

Greater knowledge concerning tumor heterogeneity and clonality is needed to determine the impact of targeted treatment in the setting of bladder cancer. In this study, we performed whole-exome, transcriptome, and deep-focused sequencing of metachronous tumors from 29 patients initially diagnosed with early-stage bladder tumors (14 with nonprogressive disease and 15 with progressive disease). Tumors from patients...

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PMID: 27488526
DOI: 10.1158/0008-5472.CAN-16-0436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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