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Article

Treatment resistance in urothelial carcinoma: an evolutionary perspective.

Nature reviews. Clinical oncology - 1 Aug 2018

Vlachostergios Panagiotis J, Faltas Bishoy M

Abstract excerpt

The emergence of treatment-resistant clones is a critical barrier to cure in patients with urothelial carcinoma. Setting the stage for the evolution of resistance, urothelial carcinoma is characterized by extensive mutational heterogeneity, which is detectable even in patients with early stage disease. Chemotherapy and immunotherapy both act as selective pressures that shape the evolutionary trajectory of...

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PMID: 29720713
DOI: 10.1038/s41571-018-0026-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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