Article
A new branch on the tree: next-generation sequencing in the study of cancer evolution.
Seminars in cell & developmental biology - 1 Apr 2012
Brosnan Jacqueline A, Iacobuzio-Donahue Christine A
Abstract excerpt
Cancer is a disease caused by the accumulation of genetic alterations in association with successive waves of clonal expansion. Mapping of the human genome sequence, in conjunction with technical advances in the ability to sequence entire genomes, have provided new insight into the mutational spectra and genetic events associated with clonal evolution of cancer. Moving forward, a clearer understanding of those...
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