Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance.

The Journal of experimental medicine - 3 Jan 2022

Li Tong, Yum Seoyun, Li Minghao, Chen Xiang, Zuo Xiaoxia, Chen Zhijian J

Abstract excerpt

Defective DNA clearance in DNase II-/- mice leads to lethal inflammatory diseases that can be rescued by deleting cGAS or STING, but the role of distinct signaling pathways downstream of STING in the disease manifestation is not known. We found that the STING S365A mutation, which abrogates IRF3 binding and type I interferon induction, rescued the embryonic lethality of DNase II-/- mice. However, the STING S365A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis
Share to Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Interferon Regulatory Factor-3

Share to Interleukin-6

Share to NF-kappa B

Share to Nucleotidyltransferases

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 34901991
DOI: 10.1084/jem.20211539
PMCID: PMC8672646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance.PMID 34901991Read ↗

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infectionsSemantic proximity Read ↗

Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and LupusSemantic proximity Read ↗

Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutantSemantic proximity Read ↗

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3Semantic proximity Read ↗

Self-DNA, STING-dependent signaling and the origins of autoinflammatory diseaseSemantic proximity Read ↗

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.Semantic proximity Read ↗

Molecular and spatial mechanisms governing STING signallingSemantic proximity Read ↗

STING-Mediated Lung Inflammation and Beyond.Semantic proximity Read ↗

Regulation of cGAS-STING pathway - Implications for systemic lupus erythematosusSemantic proximity Read ↗

Inhibition of Sting rescues lupus disease by the regulation of Lyn-mediated dendritic cell differentiationSemantic proximity Read ↗

Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and CancerSemantic proximity Read ↗

Dynamic STING repression orchestrates immune cell development and functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.