Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia.

doi:10.1186/1479-5876-10-178

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Article

Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia.

Journal of translational medicine - 29 Aug 2012

Palomba Grazia, Colombino Maria, Contu Antonio, Massidda Bruno, Baldino Giovanni, Pazzola Antonio, Ionta MariaTeresa, Capelli Francesca, Trova Vittorio, Sedda Tito, Sanna Giovanni, Tanda Francesco, Budroni Mario, Palmieri Giuseppe, Cossu Antonio, Contu Marta, Cuccu Angelo, Farris Antonio, Macciò Antonio, Mameli Giuseppe, Olmeo Nina, Ortu Salvatore, Petretto Elisabetta, Pusceddu Valeria, Virdis Luciano

Abstract excerpt

BACKGROUND: Role of KRAS, BRAF and PIK3CA mutations in pathogenesis of colorectal cancer (CRC) has been recently investigated worldwide. In this population-based study, we evaluated the incidence rates and distribution of such somatic mutations in genetically isolated population from Sardinia. METHODS: From April 2009 to July 2011, formalin-fixed paraffin-embedded tissues (N = 478) were prospectively collected...

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Identifiers

PMID: 22931052
DOI: 10.1186/1479-5876-10-178
PMCID: PMC3480926

Genes

KRAS
BRAF
EGFR

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