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Article

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2011

Chen Wenjing, Biswas Tapan, Porter Vanessa R, Tsodikov Oleg V, Garneau-Tsodikova Sylvie

Abstract excerpt

The emergence of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis (TB) is a serious global threat. Aminoglycoside antibiotics are used as a last resort to treat XDR-TB. Resistance to the aminoglycoside kanamycin is a hallmark of XDR-TB. Here, we reveal the function and structure of the mycobacterial protein Eis responsible for resistance to kanamycin in a significant fraction of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21628583
DOI: 10.1073/pnas.1105379108
PMCID: PMC3116390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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