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Article

Melting the eis: Nondetection of Kanamycin Resistance Markers by Routine Diagnostic Tests and Identification of New eis Promoter Variants.

Antimicrobial agents and chemotherapy - 17 Jun 2021

Ley Serej D, Pillay Samantha, Streicher Elizabeth M, van der Heijden Yuri F, Sirgel Frederik, Derendinger Brigitta, de Kock Marianna, Gagneux Sébastien, Warren Robin M, Theron Grant, de Vos Margaretha

Abstract excerpt

Eis promoter mutations can confer reduced Mycobacterium tuberculosis kanamycin susceptibility. GenoType MTBDRsl, a widely used assay evaluating this region, wrongly classified 17/410 isolates as eis promoter wild type. Six out of seventeen isolates harbored mutations known to confer kanamycin resistance, and the remainder harbored either novel eis promoter mutations (7/11) or disputed mutations (4/11). GenoType...

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Identifiers

PMID: 33903113
DOI: 10.1128/AAC.02502-20
PMCID: PMC8218670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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