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Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis

15 Oct 2021

Abstract excerpt

Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes. Knockdown of crb2 causes glomerular permeability defects in zebrafish, and its complete knockout causes embryonic lethality in mice. There are also reports of Crb2 mutations in patients with steroid-resistant nephrotic syndrome, although the precise mechanism is unclear. The present study demonstrated that...

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PMID: 34654837
DOI: 10.1038/s41598-021-00159-z

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