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Article

CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.

American journal of physiology. Renal physiology - 1 Oct 2000

Li C, Ruotsalainen V, Tryggvason K, Shaw A S, Miner J H

Abstract excerpt

CD2-associated protein (CD2AP) is an adapter molecule that can bind to the cytoplasmic domain of nephrin, a component of the glomerular slit diaphragm. Mice lacking CD2AP exhibit a congenital nephrotic syndrome characterized by extensive foot process effacement, suggesting that CD2AP-nephrin inte...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10997929
DOI: 10.1152/ajprenal.2000.279.4.F785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10997929-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.PMID 10997929Read ↗

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.Semantic proximity Read ↗

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CD2AP and p130Cas localize to different F-actin structures in podocytesSemantic proximity Read ↗

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The tricellular junctional protein Ildr2 helps maintain glomerular podocyte architectureSemantic proximity Read ↗

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CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS).Semantic proximity Read ↗

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survivalSemantic proximity Read ↗

Effects of the differential expression of ZO ‐1 and ZO ‐2 on podocyte structure and functionSemantic proximity Read ↗

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