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Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches

27 Sept 2021

Abstract excerpt

cells from acute myeloid leukemia (AML) and myeloproliferative neoplasm patients for up to 3 wk. Human malignant cells distributed in the bioreactor system mimicking the spatial distribution found in native BM tissue, where most HSPCs remain linked to the niches and mature cells are released to the circulation. Using human adipose tissue-derived stromal vascular fraction cells, we then generated a...

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PMID: 34580200
DOI: 10.1073/pnas.2114227118

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