Article

Deploying cross-species bone marrow niches to elucidate human hematopoietic stem cell regulation <i>in vivo</i>

2026-05-04

Abstract excerpt

The regulation of human hematopoietic stem cell (HSC) function within its native bone marrow microenvironment remains poorly understood due to the limitations of existing humanized models. Here, we present a non-conditioned human HSC xenotransplantation platform that serves as a physiologically relevant in vivo surrogate to study these complex cellular interactions. Using this system, we uncover a dynamic, cross-s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4475fb4d-958d-5c9d-9037-8e04e506a0d5
DOI: 10.64898/2026.04.30.719914

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deploying cross-species bone marrow niches to elucidate human hematopoietic stem cell regulation <i>in vivo</i>DOI 10.64898/2026.04.30.719914Read

Humanized <i>in vivo</i> bone marrow models orchestrate multi-lineage human hematopoietic cell developmentSemantic proximity Read

Bone Marrow-Derived Mesenchymal Stromal Cells: A Novel Target to Optimize Hematopoietic Stem Cell Transplantation Protocols in Hematological Malignancies and Rare Genetic DisordersSemantic proximity Read

Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cellsSemantic proximity Read

Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cellsSemantic proximity Read

In vitro biomimetic engineering of a human hematopoietic niche with functional propertiesSemantic proximity Read

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approachesSemantic proximity Read

Deciphering the evolving niche interactome of human hematopoietic stem cells from ontogeny to agingSemantic proximity Read

A novel <i>kit</i> mutant rat enables hematopoietic stem cell engraftment without irradiationSemantic proximity Read

Expansion on Stromal Cells Preserves the Undifferentiated State of Human Hematopoietic Stem Cells Despite Compromised Reconstitution AbilitySemantic proximity Read

In vivo dynamics of human hematopoietic stem cells: novel concepts and future directionsSemantic proximity Read

The HSC niche concept has turned 31Semantic proximity Read

BMP-2 generates a functional bone marrow niche by inducing the differentiation of local mesenchymal cells into CAR cellsSemantic proximity Read