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Article

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells.

Cell reports - 11 Oct 2016

Smith Bradley, Schafer Xenia L, Ambeskovic Aslihan, Spencer Cody M, Land Hartmut, Munger Joshua

Abstract excerpt

Metabolic reprogramming is critical to oncogenesis, but the emergence and function of this profound reorganization remain poorly understood. Here we find that cooperating oncogenic mutations drive large-scale metabolic reprogramming, which is both intrinsic to cancer cells and obligatory for the transition to malignancy. This involves synergistic regulation of several genes encoding metabolic enzymes, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27732857
DOI: 10.1016/j.celrep.2016.09.045
PMCID: PMC5108179

Genes

GPT2
LDHA
LDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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