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Article

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism.

Scientific reports - 25 Jan 2017

Zielinski Daniel C, Jamshidi Neema, Corbett Austin J, Bordbar Aarash, Thomas Alex, Palsson Bernhard O

Abstract excerpt

Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a remarkably consistent structure underlying high flux metabolism. The three primary uptake...

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Identifiers

PMID: 28120890
DOI: 10.1038/srep41241
PMCID: PMC5264163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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