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Article

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.

Seminars in cell & developmental biology - 1 Jun 2012

Daye Dania, Wellen Kathryn E

Abstract excerpt

Increased glutaminolysis is now recognized as a key feature of the metabolic profile of cancer cells, along with increased aerobic glycolysis (the Warburg effect). In this review, we discuss the roles of glutamine in contributing to the core metabolism of proliferating cells by supporting energy production and biosynthesis. We address how oncogenes and tumor suppressors regulate glutamine metabolism and how cells...

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Identifiers

PMID: 22349059
DOI: 10.1016/j.semcdb.2012.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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