Article
Metabolic changes in cancer: beyond the Warburg effect.
Acta biochimica et biophysica Sinica - 1 Jan 2013
Wu Weihua, Zhao Shimin
Abstract excerpt
Altered metabolism is one of the hallmarks of cancer cells. The best-known metabolic abnormality in cancer cells is the Warburg effect, which demonstrates an increased glycolysis even in the presence of oxygen. However, tumor-related metabolic abnormalities are not limited to altered balance between glucose fermentation and oxidative phosphorylation. Key tumor genes such as p53 and c-myc are found to be master...
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