Article
Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro.
Oncotarget - 6 Dec 2016
Bessède Emilie, Molina Silvia, Acuña-Amador Luis, Dubus Pierre, Staedel Cathy, Chambonnier Lucie, Buissonnière Alice, Sifré Elodie, Giese Alban, Bénéjat Lucie, Rousseau Benoît, Costet Pierre, Sacks David B, Mégraud Francis, Varon Christine
Abstract excerpt
Helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. IQGAP1, a scaffolding protein of the adherens junctions interacting with E-cadherin, regulates cellular plasticity and proliferation. In mice, IQGAP1 deficiency leads to gastric hyperplasia. The aim of this study was to elucidate the consequences of IQGAP1 deletion on H. pylori-induced gastric...
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