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Article

Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair

8 Dec 2020

Abstract excerpt

OBJECTIVE: Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN: mouse model. Depletion of Iqgap3 revealed its functional importance in maintenance and proliferation of stem cells. We further studied Iqgap3 expression and the...

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PMID: 33293280
DOI: 10.1136/gutjnl-2020-322779

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