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Single-cell profiling uncovers a <i>Muc4</i> -expressing metaplastic gastric cell type sustained by <i>Helicobacter pylori</i> -specific inflammation

2022-12-20

Abstract excerpt

<h4> Abstract </h4> Mechanisms for Helicobacter pylori ( Hp )-driven stomach cancer are not fully understood. In a transgenic mouse model of gastric preneoplasia, concomitant Hp infection and induction of constitutively active KRAS ( Hp +KRAS+) alters metaplasia phenotypes and elicits greater inflammation than either perturbation alone. Gastric single-cell RNA-seq showed that Hp +KRAS+ mice had a large popu...

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Literature Corpus work
a1980eea-44e7-5b22-92e1-a42c4580e0e9
DOI
10.1101/2022.12.20.521287
Open publication

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Single-cell profiling uncovers a <i>Muc4</i> -expressing metaplastic gastric cell type sustained by <i>Helicobacter pylori</i> -specific inflammationDOI 10.1101/2022.12.20.521287
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