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Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes.

Oncogene - 7 Aug 2014

Bessède E, Staedel C, Acuña Amador L A, Nguyen P H, Chambonnier L, Hatakeyama M, Belleannée G, Mégraud F, Varon C

Abstract excerpt

Helicobacter pylori infection is the major risk factor for gastric adenocarcinoma. The link with gastric adenocarcinoma is partly due to the H. pylori CagA oncoprotein. CagA is responsible for a particular cell phenotype in vitro, the 'hummingbird' phenotype, that corresponds to an elongation of the cells, mimicking an epithelial-mesenchymal transition (EMT). EMT participates in the carcinogenesis process, and is...

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PMID: 24096479
DOI: 10.1038/onc.2013.380

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