Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Giannakis Marios, Chen Swaine L, Karam Sherif M, Engstrand Lars, Gordon Jeffrey I

Abstract excerpt

We have characterized the adaptations of Helicobacter pylori to a rarely captured event in the evolution of its impact on host biology-the transition from chronic atrophic gastritis (ChAG) to gastric adenocarcinoma-and defined the impact of these adaptations on an intriguing but poorly characterized interaction between this bacterium and gastric epithelial stem cells. Bacterial isolates were obtained from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Separation
Share to Chronic Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoscopy

Share to Gastritis, Atrophic

Share to Genome, Bacterial

Share to Helicobacter pylori

Share to Stem Cells

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 18332421
DOI: 10.1073/pnas.0800668105
PMCID: PMC2393758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.PMID 18332421Read ↗

The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression.Semantic proximity Read ↗

Stem Cells, Helicobacter pylori, and Mutational Landscape: Utility of Preclinical Models to Understand Carcinogenesis and to Direct Management of Gastric Cancer.Semantic proximity Read ↗

Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.Semantic proximity Read ↗

The Landscape of Helicobacter pylori-related Gastric CarcinogenesisSemantic proximity Read ↗

<i>Helicobacter pylori</i> chronic infection selects for effective colonizers of metaplastic glandsSemantic proximity Read ↗

Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes.Semantic proximity Read ↗

Ten years after the first Helicobacter pylori genome: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen.Semantic proximity Read ↗

Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progressionSemantic proximity Read ↗

A comprehensive analysis of single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancerSemantic proximity Read ↗

Single-cell profiling uncovers a <i>Muc4</i> -expressing metaplastic gastric cell type sustained by <i>Helicobacter pylori</i> -specific inflammationSemantic proximity Read ↗

Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric CancerSemantic proximity Read ↗

Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.