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Article

Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.

Gastroenterology - 1 Jun 2015

Sigal Michael, Rothenberg Michael E, Logan Catriona Y, Lee Josephine Y, Honaker Ryan W, Cooper Rachel L, Passarelli Ben, Camorlinga Margarita, Bouley Donna M, Alvarez Guillermo, Nusse Roeland, Torres Javier, Amieva Manuel R

Abstract excerpt

BACKGROUND & AIMS: Helicobacter pylori infection is the main risk factor for gastric cancer. We characterized the interactions of H pylori with gastric epithelial progenitor and stem cells in humans and mice and investigated how these interactions contribute to H pylori-induced pathology. METHODS: We used quantitative confocal microscopy and 3-dimensional reconstruction of entire gastric glands to determine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25725293
DOI: 10.1053/j.gastro.2015.02.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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