Article
DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1.
Journal of hematology & oncology - 10 Oct 2016
Xu Jie, Zhang Wu, Yan Xiao-Jing, Lin Xue-Qiu, Li Wei, Mi Jian-Qing, Li Jun-Min, Zhu Jiang, Chen Zhu, Chen Sai-Juan
Abstract excerpt
BACKGROUND: DNMT3A mutations are frequently discovered in acute myeloid leukemia (AML), associated with poor outcome. Recently, a relapse case report of AML extramedullary disease has showed that AML cells harboring DNMT3A variation were detected in the cerebral spinal fluid. However, whether a causal relationship exists between DNMT3A mutation (D3Amut) and extramedullary infiltration (EMI) is unclear. METHODS:...
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