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Article

Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation.

Frontiers in immunology - 1 Jan 2021

Que Yimei, Li Huimin, Lin Liman, Zhu Xiaojian, Xiao Min, Wang Ying, Zhu Li, Li Dengju

Abstract excerpt

DNA (cytosine-5)-methyltransferase 3A (DNMT3A)-mutated acute myeloid leukemia (AML) has a poor prognosis, but the exact mechanism is still unclear. Here, we aimed to explore the mechanism of immune escape in AML with DNMT3A mutation. We constructed a DNMT3A knockout clone and DNMT3A-R882H-mutated clones. RNA-seq results showed that transcription factors and macrophage inflammatory proteins were significantly...

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Identifiers

PMID: 34093541
DOI: 10.3389/fimmu.2021.653030
PMCID: PMC8173207

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