Article
High Frequency of GBA Gene Mutations in Dementia With Lewy Bodies Among Ashkenazi Jews.
JAMA neurology - 1 Dec 2016
Shiner Tamara, Mirelman Anat, Gana Weisz Mali, Bar-Shira Anat, Ash Elissa, Cialic Ron, Nevler Naomi, Gurevich Tanya, Bregman Noa, Orr-Urtreger Avi, Giladi Nir
Abstract excerpt
IMPORTANCE: Mutations in the glucocerebrosidase (GBA) gene are a risk factor for the development of dementia with Lewy bodies (DLB). These mutations are common among Ashkenazi Jews (AJ) and appear to have an effect on the natural history of the disease. OBJECTIVES: To evaluate the clinical and genetic characteristics of an AJ cohort of patients diagnosed with DLB, assess the association of phenotype of DLB with...
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