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Article

Effect of GBA1 Mutations and APOE Polymorphisms on Survival and Progression Among Ashkenazi Jews with Dementia with Lewy Bodies.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2024

Shiner Tamara, Kavé Gitit, Mirelman Anat, Regev Keren, Piura Yoav, Goldstein Orly, Gana Weisz Mali, Bar-Shira Anat, Gurevich Tanya, Orr-Urtreger Avi, Alcalay Roy N, Giladi Nir, Bregman Noa

Abstract excerpt

BACKGROUND: Glucocerebrosidase 1 (GBA1) mutations are associated with reduced survival in Parkinson's disease but their effect on survival in dementia with Lewy bodies (DLB) is unclear. OBJECTIVE: To assess the impact of GBA1 mutations on survival among Ashkenazi Jews with DLB, while controlling for APOE status. METHODS: One hundred and forty participants from Tel Aviv Medical Center, Israel were genotyped for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39212252
DOI: 10.1002/mds.30003
PMCID: PMC11657010

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