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Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A mini-review.

Neuroscience and biobehavioral reviews - 1 Oct 2022

Gaubert Sinead, Hourregue Claire, Mouton-Liger François, Millot Périne, Franco Mélanie, Amar-Bouaziz Elodie, Aarsland Dag, Hugon Jacques, Paquet Claire

Abstract excerpt

IMPORTANCE: Dementia with Lewy bodies (DLB) is a neurodegenerative disease linked to abnormal accumulation of phosphorylated α-synuclein. GBA1 is the gene encoding the lysosomal enzyme glucocerebrosidase (GCase), whose mutations are a risk factor of DLB. OBJECTIVE: To report all available data exploring the association between GBA1 mutations and DLB. EVIDENCE REVIEW: All publications focused on GCase and DLB in...

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PMID: 36084847
DOI: 10.1016/j.neubiorev.2022.104856

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