Article
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
Archives of neurology - 1 Mar 2008
Mata Ignacio F, Samii Ali, Schneer Seth H, Roberts John W, Griffith Alida, Leis Berta C, Schellenberg Gerard D, Sidransky Ellen, Bird Thomas D, Leverenz James B, Tsuang Debby, Zabetian Cyrus P
Abstract excerpt
BACKGROUND: Mutations in the glucocerebrosidase (GBA) gene have been reported to modify risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these findings have not been consistently replicated, and most studies have had substantial methodological shortcomings. OBJECTIVE: To better assess the role of GBA variants in altering risk for Lewy body disorders. DESIGN: Case-control study....
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