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A Global Perspective of GBA1-Related Parkinson's Disease: A Narrative Review.

Genes - 16 Dec 2024

Koros Christos, Bougea Anastasia, Alefanti Ioanna, Simitsi Athina Maria, Papagiannakis Nikolaos, Pachi Ioanna, Sfikas Evangelos, Antonelou Roubina, Stefanis Leonidas

Abstract excerpt

Parkinson's disease (PD) is considered to be the second most prominent neurodegenerative disease and has a global prevalence. Glucocerebrosidase (GBA1) gene mutations represent a significant hereditary risk factor for the development of PD and have a profound impact on the motor and cognitive progression of the disease. The aim of this review is to summarize the literature data on the prevalence, type, and...

Topics

Humans
Glucosylceramidase
Parkinson Disease
Mutation
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39766872
DOI: 10.3390/genes15121605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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