Article
Association of glucocerebrosidase mutations with dementia with lewy bodies.
Archives of neurology - 1 May 2009
Clark Lorraine N, Kartsaklis Lykourgos A, Wolf Gilbert Rebecca, Dorado Beatriz, Ross Barbara M, Kisselev Sergey, Verbitsky Miguel, Mejia-Santana Helen, Cote Lucien J, Andrews Howard, Vonsattel Jean-Paul, Fahn Stanley, Mayeux Richard, Honig Lawrence S, Marder Karen
Abstract excerpt
BACKGROUND: Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders. OBJECTIVE: To determine the relationship of GBA mutations and APOE4 genotype to LB and Alzheimer disease (AD) pathological findings. DESIGN: Case-control study. SETTING: Academic research. PARTICIPANTS: The 187 subjects included patients with primary neuropathological diagnoses of LB disorders with or without...
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