Article
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.
Neurology - 6 Nov 2012
Tsuang Debby, Leverenz James B, Lopez Oscar L, Hamilton Ronald L, Bennett David A, Schneider Julie A, Buchman Aron S, Larson Eric B, Crane Paul K, Kaye Jeffrey A, Kramer Patricia, Woltjer Randy, Kukull Walter, Nelson Peter T, Jicha Gregory A, Neltner Janna H, Galasko Doug, Masliah Eliezer, Trojanowski John Q, Schellenberg Gerard D, Yearout Dora, Huston Haley, Fritts-Penniman Allison, Mata Ignacio F, Wan Jia Y, Edwards Karen L, Montine Thomas J, Zabetian Cyrus P
Abstract excerpt
OBJECTIVES: Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized by Lewy body disease (LBD) neuropathologic changes (LBDNCs). We sought to determine whether GBA influences risk of dementia with LBDNCs, Alzheimer disease (AD) neuropathologic changes (ADNCs), or both. METHODS: We screened the entire GBA coding...
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