Article
MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD.
Redox biology - 1 Feb 2023
Korn Lisanne, Speicher Anna M, Schroeter Christina B, Gola Lukas, Kaehne Thilo, Engler Alexander, Disse Paul, Fernández-Orth Juncal, Csatári Júlia, Naumann Michael, Seebohm Guiscard, Meuth Sven G, Schöler Hans R, Wiendl Heinz, Kovac Stjepana, Pawlowski Matthias
Abstract excerpt
Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar degeneration (FTLD)-tau, which span a wide phenotypic and pathological spectrum. Some of these mutations, such as the N279K mutation, result in a shift of the physiological 3R/4R ratio towards the more aggregation prone 4R isoform. Other...
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