Article
Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.
Oncogene - 6 Apr 2017
Tran T Q, Lowman X H, Reid M A, Mendez-Dorantes C, Pan M, Yang Y, Kong M
Abstract excerpt
Cancer cells depend on glutamine to sustain their increased proliferation and manage oxidative stress, yet glutamine is often depleted at tumor sites owing to excessive cellular consumption and poor vascularization. We have previously reported that p53 protein, although a well-known tumor suppressor, can contribute to cancer cell survival and adaptation to low-glutamine conditions. However, the TP53 gene is...
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