Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT4 Protein Suppresses Tumor Formation in Genetic Models of Myc-induced B Cell Lymphoma

25 Dec 2013

Abstract excerpt

Glutamine metabolism plays an essential role for growth and proliferation of many cancer cells by providing metabolites for the maintenance of mitochondrial functions and macromolecular synthesis. Aberrant activation of the transcription factor c-Myc, e.g. caused by t(8;14) chromosomal translocation commonly found in Burkitt lymphoma, is a key driver of cellular glutamine metabolism in many tumors, highlighting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24368766
DOI: 10.1074/jbc.m113.525949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT4 Protein Suppresses Tumor Formation in Genetic Models of Myc-induced B Cell LymphomaPMID 24368766Read ↗

Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancerSemantic proximity Read ↗

Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer DevelopmentSemantic proximity Read ↗

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.Semantic proximity Read ↗

Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)Semantic proximity Read ↗

Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.Semantic proximity Read ↗

SIRT4 functions as a tumor suppressor in prostate cancer by inducing apoptosis and inhibiting glutamine metabolismSemantic proximity Read ↗

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2Semantic proximity Read ↗

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.Semantic proximity Read ↗

The PIK3CA-E545K-SIRT4 signaling axis reduces radiosensitivity by promoting glutamine metabolism in cervical cancer.Semantic proximity Read ↗

Increased glutaminolytic flux and activation of mitochondrial metabolism by BCL2 hyperactivity in lymphomaSemantic proximity Read ↗

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Advances in Understanding of Metabolism of B-Cell Lymphoma: Implications for TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.